Autoimmune liver disease: novelties in management.

Nedim Hadzic, Loreto Hierro

Journal: Clinics and research in hepatology and gastroenterology 2015;38(3):273-6

PMID: 24767608

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Abstract

Autoimmune liver disease is the second commonest cause of chronic liver disease in teenagers. There are several forms including autoimmune hepatitis, autoimmune sclerosing cholangitis, primary sclerosing cholangitis and various overlap syndromes, classified on the basis of different serum antibody profiles, histological features and appearances on cholangiography. Treatment with immunosupressants is usually effective, but often required medium to long-term, raising concerns about side effects and adherence to therapy. For a minority of children presenting in acute liver failure or with difficult-to-treat disease liver transplantation is a possible option, although risk of recurrence in the grafted liver remains lifelong.

Address: Pediatric Centre for Hepatology, Gastroenterology and Nutrition, King's College Hospital, Denmark Hill, London, UK. Electronic address: [email protected].; Pediatric Liver Service, La Paz Children's University Hospital, Madrid, Spain.

DOI: 10.1016/j.clinre.2014.03.015

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MeSH Terms: Anti-Bacterial Agents, Antibodies, Autoimmune Diseases, Cholangiography, Cholangiopancreatography, Magnetic Resonance, Glucocorticoids, Humans, Immunosuppressive Agents, Liver Diseases, Vancomycin