MeCP2: the long trip from a chromatin protein to neurological disorders.

Juan Ausió, Alexia Martínez de Paz, Manel Esteller

Journal: Trends in molecular medicine 2015;20(9):487-98

PMID: 24766768

Full Text on Elsevier Science View on PubMed

Abstract

Since the discovery of its fundamental involvement in Rett syndrome, methyl CpG binding protein 2 (MeCP2) has been the focus of an exhaustive biochemical and functional characterization. It is now becoming apparent that the intrinsic highly disordered nature of MeCP2, which is amenable to a plethora of post-translational modifications (PTMs), allows it to recognize a large number of protein interacting partners, including histones. MeCP2 is highly abundant in the brain and it is an important component of neuronal chromatin; nevertheless, the organization and implications of its involvement in terms of DNA methylation binding dependence and effects on transcription are still not well understood. Recent results have shown that MeCP2 plays an important role in brain development, aging, and in neurological disorders.

Address: Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Av. Gran Via de L'Hospitalet 199-203, L'Hospitalet del Llobregat, Barcelona, Catalonia, Spain; Department of Biochemistry and Microbiology, University of Victoria, British Columbia, V8W 3P6, Canada. Electronic address: [email protected].; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Av. Gran Via de L'Hospitalet 199-203, L'Hospitalet del Llobregat, Barcelona, Catalonia, Spain.; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Av. Gran Via de L'Hospitalet 199-203, L'Hospitalet del Llobregat, Barcelona, Catalonia, Spain; Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain. Electronic address: [email protected].

DOI: 10.1016/j.molmed.2014.03.004

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MeSH Terms: Aging, Amino Acid Sequence, Brain, Chromatin, DNA Methylation, Histones, Humans, Methyl-CpG-Binding Protein 2, Molecular Sequence Data, Neurodegenerative Diseases, Protein Processing, Post-Translational, Transcription, Genetic