Genus Kadsura, a good source with considerable characteristic chemical constituents and potential bioactivities.

Jiushi Liu, Yaodong Qi, Hongwu Lai, Jin Zhang, Xiaoguang Jia, Haitao Liu, Bengang Zhang, Peigen Xiao

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 2015;21(8-9):1092-7

PMID: 24784528

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Abstract

In China, the plants of genus Kadsura had been used as the folk medicines for a long time and showed good effect of activating blood and dissolving stasis, promoting qi circulation to relieve pain, dispelling wind and eliminating dampness. The bioactivities of genus Kadsura were attributed to the existence of its characteristic chemical constituents. This review systematically summarized the traditional efficacy and medicinal application of genus Kadsura in China, chemical constituents and bioactivities of the plants of genus Kadsura. And, lignans and triterpenoids were the main bioactive constituents, which exhibited good anti-HIV, anti-tumor, anti-hepatitis, anti-oxidant, anti-platelet aggregation activities and neuroprotective effect etc. Moreover, some structure-activity relationships mining would greatly enrich the opportunity of finding new and promising lead compounds and promote the reasonable development and utilization of the plants of genus Kadsura.

Address: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Peking Union Medical College), Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.; Xinjiang Institute of Chinese and Ethnic Medicine, Urumqi 830002, Xinjiang, China.; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Peking Union Medical College), Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China; Xinjiang Institute of Chinese and Ethnic Medicine, Urumqi 830002, Xinjiang, China. Electronic address: [email protected].; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Peking Union Medical College), Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China. Electronic address: [email protected].

DOI: 10.1016/j.phymed.2014.01.015

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MeSH Terms: Antineoplastic Agents, Phytogenic, Antioxidants, Antiviral Agents, China, Drugs, Chinese Herbal, Kadsura, Lignans, Medicine, Traditional, Molecular Structure, Neuroprotective Agents, Nitric Oxide, Plants, Medicinal, Platelet Aggregation, Structure-Activity Relationship, Treatment Outcome, Triterpenes