Mitochondrial cardiolipin/phospholipid trafficking: the role of membrane contact site complexes and lipid transfer proteins.

Uwe Schlattner, Malgorzata Tokarska-Schlattner, Denis Rousseau, Mathieu Boissan, Carmen Mannella, Richard Epand, Marie-Lise Lacombe

Journal: Chemistry and physics of lipids 2014;179():32-41

PMID: 24373850

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Abstract

Historically, cellular trafficking of lipids has received much less attention than protein trafficking, mostly because its biological importance was underestimated, involved sorting and translocation mechanisms were not known, and analytical tools were limiting. This has changed during the last decade, and we discuss here some progress made in respect to mitochondria and the trafficking of phospholipids, in particular cardiolipin. Different membrane contact site or junction complexes and putative lipid transfer proteins for intra- and intermembrane lipid translocation have been described, involving mitochondrial inner and outer membrane, and the adjacent membranes of the endoplasmic reticulum. An image emerges how cardiolipin precursors, remodeling intermediates, mature cardiolipin and its oxidation products could migrate between membranes, and how this trafficking is involved in cardiolipin biosynthesis and cell signaling events. Particular emphasis in this review is given to mitochondrial nucleoside diphosphate kinase D and mitochondrial creatine kinases, which emerge to have roles in both, membrane junction formation and lipid transfer.

Address: Univ. Grenoble-Alpes, Laboratory of Fundamental and Applied Bioenergetics (LBFA) and SFR Environmental and Systems Biology (BEeSy), Grenoble, France; Inserm, U1055, Grenoble, France. Electronic address: [email protected].; Univ. Grenoble-Alpes, Laboratory of Fundamental and Applied Bioenergetics (LBFA) and SFR Environmental and Systems Biology (BEeSy), Grenoble, France; Inserm, U1055, Grenoble, France.; UPMC Université Paris 06, Paris, France; Inserm, UMRS938, Paris, France; Hôpital Tenon, AP-HP, Service de Biochimie et Hormonologie, Paris, France.; Wadsworth Center, New York State Department of Health, Albany, NY, USA.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; UPMC Université Paris 06, Paris, France; Inserm, UMRS938, Paris, France.

DOI: 10.1016/j.chemphyslip.2013.12.008

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MeSH Terms: Biological Transport, Cardiolipins, Carrier Proteins, Intracellular Membranes, Mitochondria, Mitochondrial Membranes