Stepping towards causation in studies of neighborhood and environmental effects: how twin research can overcome problems of selection and reverse causation.

Glen E Duncan, Brianna Mills, Eric Strachan, Philip Hurvitz, Ruizhu Huang, Anne Vernez Moudon, Eric Turkheimer

Journal: Health & place 2015;27():106-11

PMID: 24594837

Abstract

No causal evidence is available to translate associations between neighborhood characteristics and health outcomes into beneficial changes to built environments. Observed associations may be causal or result from uncontrolled confounds related to family upbringing. Twin designs can help neighborhood effects studies overcome selection and reverse causation problems in specifying causal mechanisms. Beyond quantifying genetic effects (i.e., heritability coefficients), we provide examples of innovative measures and analytic methods that use twins as quasi-experimental controls for confounding by environmental effects. We conclude that collaboration among investigators from multiple fields can move the field forward by designing studies that step toward causation.

Copyright © 2014 Elsevier Ltd. All rights reserved.

Address: Department of Epidemiology, University of Washington, Seattle, WA 98195, USA; Interdisciplinary Graduate Program in Nutritional Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address: [email protected].; Department of Epidemiology, University of Washington, Seattle, WA 98195, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA.; Department of Urban Design and Planning, Urban Form Lab, University of Washington, Seattle, WA 98195, USA.; Interdisciplinary PhD Program in Urban Design and Planning, Urban Form Lab, University of Washington, Seattle, WA 98195, USA.; Department of Epidemiology, University of Washington, Seattle, WA 98195, USA; Department of Urban Design and Planning, Urban Form Lab, University of Washington, Seattle, WA 98195, USA.; Department of Psychology, University of Virginia, Charlottesville, VA 22904, USA.
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