New developments in 'ene'-reductase catalysed biological hydrogenations.

Helen S Toogood, Nigel S Scrutton

Journal: Current opinion in chemical biology 2014;19():107-15

PMID: 24608082

Full Text on Elsevier Science View on PubMed

Abstract

Asymmetric biocatalytic hydrogenations are important reactions performed primarily by members of the Old Yellow Enzyme family. These reactions have great potential in the chemosynthesis of a variety of industrially useful synthons due to the generation of up to two stereogenic centres. In this review, additional enzyme classes capable of asymmetric hydrogenations will be discussed, as will examples of multienzyme cascading reactions. New and improved technology that enhances the commercial viability of biotransformations are included, such as the nicotinamide coenzyme-independent reactions. This review will focus on progress in this field within the last two years, with emphasis on industrial applications of this technology.

Address: Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.; Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, 131 Princess Street, Manchester M1 7DN, UK. Electronic address: [email protected].

DOI: 10.1016/j.cbpa.2014.01.019

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MeSH Terms: Biocatalysis, Humans, Hydrogenation, Oxidoreductases, Protein Engineering, Stereoisomerism, Substrate Specificity