Preliminary evidence that early reduction in p11 levels in natural killer cells and monocytes predicts the likelihood of antidepressant response to chronic citalopram.

P Svenningsson, L Berg, D Matthews, D F Ionescu, E M Richards, M J Niciu, A Malinger, M Toups, H Manji, M H Trivedi, C A Zarate, P Greengard

Journal: Molecular psychiatry 2015;19(9):962-4

PMID: 24614495

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Abstract

The prediction of treatment response in many neuropsychiatric disorders would be facilitated by easily accessible biomarkers. Using flow cytometry, we herein demonstrate correlations between early reductions of p11 levels in Natural Killer (NK) cells and monocytes and antidepressant response to citalopram in patients with major depressive disorder (MDD).

Address: Department of Clinical Neuroscience, Stockholm, Sweden.; Department of Medicine, Karolinska Institute, Stockholm, Sweden.; Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, Bethesda, MD, USA.; Department of Psychiatry and the Mood Disorders Research Program and Clinic, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY, USA.

DOI: 10.1038/mp.2014.13

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MeSH Terms: Adult, Annexin A2, Antidepressive Agents, Biomarkers, Pharmacological, Citalopram, Depressive Disorder, Major, Female, Flow Cytometry, Humans, Killer Cells, Natural, Male, Monocytes, S100 Proteins