Recent progress in development of synthetic biology platforms and metabolic engineering of Corynebacterium glutamicum.

Han Min Woo, Jin-Byung Park

Journal: Journal of biotechnology 2014;180():43-51

PMID: 24632177

Full Text on Elsevier Science View on PubMed

Abstract

The paradigm of synthetic biology has been evolving, along with relevant engineering, to achieve designed bio-systems. Synthetic biology has reached the point where it is possible to develop microbial strains to produce desired chemicals. Recent advances in this field have promoted metabolic engineering of Corynebacterium glutamicum as an amino-acid producer for use in intelligent microbial-cell factories. Here, we review recent advances that address C. glutamicum as a potential model organism for synthetic biology, and evaluate their industrial applications. Finally, we highlight the perspective of developing C. glutamicum as a step toward advanced microbial-cell factories that could produce valuable chemicals from renewable resources.

Address: Clean Energy Research Center, Korea Institute of Science and Technology, Seoul 136-791, Republic of Korea; Green School, Korea University, Seoul 136-701, Republic of Korea; Department of Clean Energy and Chemical Engineering, University of Science and Technology (UST), 217 Gajeong-ro, Yuseong-gu, Daejeon 305-350, Republic of Korea. Electronic address: [email protected].; Department of Food Science and Engineering, Ewha Womans University, Seoul 120-750, Republic of Korea.

DOI: 10.1016/j.jbiotec.2014.03.003

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MeSH Terms: Corynebacterium glutamicum, Industrial Microbiology, Metabolic Engineering, Synthetic Biology