The barrier to HIV transmission provided by genital tract Lactobacillus colonization.

Gregory T Spear, Paria Mirmonsef

Journal: American journal of reproductive immunology (New York, N.Y. : 1989) 2015;71(6):531-6

PMID: 24661438

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Abstract

While resistance to HIV transmission is due to multiple mechanisms such as the epithelium, a lower genital tract microbiota dominated by Lactobacillus appears to play an important role. This article reviews selected recent research on genital tract microbiota in women including how microbiota impacts HIV resistance and factors affecting Lactobacillus colonization.

Address: Department of Immunology/Microbiology, Rush University Medical Center, Chicago, IL, USA.

DOI: 10.1111/aji.12232

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MeSH Terms: Cervix Uteri, Epithelium, Female, Glycogen, HIV Infections, Humans, Hydrogen Peroxide, Immunity, Innate, Lactobacillus, Microbiota, Vagina