Methodologies for measurement of cardiac markers.

Patrick M Sluss

Journal: Clinics in laboratory medicine 2014;34(1):167-85, viii

PMID: 24507795

Full Text on Elsevier Science View on PubMed

Abstract

Antibody-based tests are the primary technology used for clinical measurement of cardiac biomarkers in peripheral circulation. This article focuses on the principles of immunometric methods that have been applied to cardiac biomarkers of widespread clinical utility (CKMB, Troponins, and B-type natriuretic proteins) and of more recent clinical testing (ST2, Galectin-2, and myosin binding protein C). How these principles are applied in the design of immunometric assays and how they influence assay performance in quantifying cardiac biomarkers in biologic fluids (serum or plasma) is discussed.

Address: Pathology Service, Clinical Pathology Core Laboratories (Special Chemistry), Pathology, Massachusetts General Hospital, Harvard Medical School, GRB554, 55 Fruit Street, Boston, MA 02114, USA. Electronic address: [email protected].

DOI: 10.1016/j.cll.2013.11.012

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MeSH Terms: Biomarkers, Carrier Proteins, Creatine Kinase, Diagnostic Techniques, Cardiovascular, Galectin 3, Heart Diseases, Humans, Interleukin-1 Receptor-Like 1 Protein, Models, Cardiovascular, Natriuretic Peptide, Brain, Point-of-Care Systems, Receptors, Cell Surface, Troponin