Quinone derivatives from the genus Rubia and their bioactivities.

Kuo Xu, Penglong Wang, Lin Wang, Congmin Liu, Shixun Xu, Yatao Cheng, Yanhui Wang, Qiang Li, Haimin Lei

Journal: Chemistry & biodiversity 2014;11(3):341-63

PMID: 24634067

Abstract

The extracts and phytochemicals of the genus Rubia have drawn much attention due to their potent effects; among them, naphthoquinone and cyclopeptide derivatives, with significant biological activities, have great potential to be developed to new drugs. This review updates and compiles a total of 142 quinone derivatives including anthraquinone and naphthoquinone derivatives, occuring in twelve Rubia species. These compounds were listed together with their sources, melting points, bioactivities, as well as 112 corresponding references. Furthermore, the structureactivity relationships of these quinone derivatives were discussed.

Address: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, P. R. China, (phone: +86-1084738640; fax: +86-1082686933).

DOI: 10.1002/cbdv.201200173

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https://doi.org/10.1002/cbdv.201200173

MeSH Terms: Anti-Infective Agents, Anti-Inflammatory Agents, Antineoplastic Agents, Antiviral Agents, Apoptosis, Bacteria, Hepatitis Viruses, Humans, Platelet Aggregation Inhibitors, Quinones, Rubia