Metabolic syndrome, insulin resistance, circadian disruption, antioxidants and pancreatic carcinoma: an overview.

Aldo Giudice, Anna Crispo, Galdiero Massimiliano, Giovanni D'Arena, Mario Felice Tecce, Maria Grimaldi, Alfonso Amore, Emanuela Esposito, Maurizio Montella

Journal: Journal of gastrointestinal and liver diseases : JGLD 2015;23(1):73-7

PMID: 24689100

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Abstract

The incidence and number of deaths caused by pancreatic tumours have been gradually rising, while the incidence and mortality of other common cancers have been declining. Risk factors for this malignant disease include cigarette smoking, family history of chronic pancreatitis, advancing age, male sex, diabetes mellitus, obesity, non-0 blood group, a high-fat diet, alcohol consumption and possibly Helicobacter pylori and hepatitis B virus infections. Metabolic diseases have become the leading cause of death in many countries. Our paper serves as a focused and updated discussion about the development of novel preventive strategies for this deadly disease.

Address: Epidemiology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Giovanni Pascale - IRCCS - Naples, Italy. [email protected].; Epidemiology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Giovanni Pascale - IRCCS - Naples, Italy.; Department of Experimental Medicine II University of Naples, Italy.; Department of Onco- Hematology, IRCCS Centro di Riferimento Oncologico della Basilicata,Rionero in Vulture, Italy.; Department of Pharmacy, University of Salerno, Salerno, Italy.; Department of Surgery, Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Giovanni Pascale - IRCCS, Naples, Italy.; Department of Surgery, Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Giovanni Pascale - IRCCS, Naples Italy.

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Free resources

Medical:

https://medlineplus.gov/pancreaticcancer.html

MeSH Terms: Antioxidants, Chronobiology Disorders, Circadian Clocks, Humans, Insulin Resistance, Metabolic Syndrome, Pancreatic Neoplasms, Risk Factors