Nonpharmacologic and pharmacologic management of CPP crystal arthritis and BCP arthropathy and periarticular syndromes.

Ann K Rosenthal, Lawrence M Ryan

Journal: Rheumatic diseases clinics of North America 2014;40(2):343-56

PMID: 24703351

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Abstract

Calcium crystal arthritis is often unrecognized, poorly managed, and few effective therapies are available. The most common types of calcium crystals causing musculoskeletal syndromes are calcium pyrophosphate (CPP) and basic calcium phosphate (BCP). Associated syndromes have different clinical presentations and divergent management strategies. Acute CPP arthritis is treated similarly to acute gouty arthritis, whereas chronic CPP and BCP arthropathy may respond to strategies used for osteoarthritis. Calcific tendonitis is treated with a variety of interventions designed to dissolve BCP crystals. A better understanding of the causes and larger well-planned trials of current therapies will lead to improved care.

Address: Division of Rheumatology, Department of Medicine, Zablocki VA Medical Center and The Medical College of Wisconsin, FEOB 4th Floor, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA. Electronic address: [email protected].; Division of Rheumatology, Department of Medicine, Zablocki VA Medical Center and The Medical College of Wisconsin, FEOB 4th Floor, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA.

DOI: 10.1016/j.rdc.2014.01.010

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MeSH Terms: Adrenal Cortex Hormones, Anti-Inflammatory Agents, Anti-Inflammatory Agents, Non-Steroidal, Antirheumatic Agents, Calcinosis, Calcium Phosphates, Chondrocalcinosis, Colchicine, Durapatite, Gout Suppressants, High-Energy Shock Waves, Humans, Interleukin 1 Receptor Antagonist Protein, Periarthritis, Tendinopathy