Plant polyphenols in the treatment of age-associated diseases: revealing the pleiotropic effects of icariin by network analysis.

Jan Kevin Schluesener, Hermann Schluesener

Journal: Molecular nutrition & food research 2014;58(1):49-60

PMID: 24311544

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Abstract

Polyphenols are a broad class of compounds. Some are ingested in substantial quantities from nutritional sources, more are produced by medicinal plants, and some of them are taken as drugs. It is becoming clear, that a single polyphenol is impacting several cellular pathways. Thus, a network approach is becoming feasible, describing the interaction of a single polyphenol with cellular networks. Here we have selected icariin to draw a prototypic network of icariin activities. Icariin appears to be a promising drug to treat major age-related diseases, like neurodegeneration, memory and depressive disorders, chronic inflammation, diabetes, and osteoporosis. It interacts with several relevant pathways, like PDE, TGF-ß, MAPK, PPAR, NOS, IGF, Sirtuin, and others. Such networks will be useful to future comparative studies of complex effects of polyphenols.

Address: Division of Immunopathology of the Nervous System, Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tuebingen, Tuebingen, Germany.

DOI: 10.1002/mnfr.201300409

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MeSH Terms: Aging, Cardiomyopathies, Cyclic Nucleotide Phosphodiesterases, Type 5, Flavonoids, Gene Expression, Humans, Inflammation, Liver Diseases, Muscular Diseases, Neurodegenerative Diseases, Nitric Oxide Synthase, Osteoporosis, PPAR alpha, Polyphenols, Sirtuin 1