The influence of sulfathiazole on the macroalgae Ulva lactuca.

Sara Leston, Margarida Nunes, Ivan Viegas, Carolina Nebot, Alberto Cepeda, Miguel Ângelo Pardal, Fernando Ramos

Journal: Chemosphere 2014;100():105-10

PMID: 24393561

Abstract

Sulfonamides (SA) are a class of antibiotics routinely found in environmental matrices and therefore their role as contaminants should be investigated in non-target organisms. With this purpose the present experimental work has evaluated the exposure of the chlorophycean Ulva lactuca L. to sulfathiazole (STZ), a SA drug commonly used in aquaculture, at two concentrations representing prophylactic (25 μg mL(-1)) and therapeutic (50 μg mL(-1)) administrations. Results showed that STZ exhibits high stability in seawater with only 18% degradation over the 5d assay at both dosages tested. Also, macroalgae demonstrated an efficient uptake capacity with constant internal concentrations after 24h regardless of the external solutions and thus should be considered as a bioindicator species in risk assessment. Both STZ concentrations induced a slight inhibition of the macroalgae growth after 96 h.

Address: CFE - Centre for Functional Ecology, Department of Life Sciences, University of Coimbra, Apartado 3046, 3001-401 Coimbra, Portugal; CEF - Center for Pharmaceutical Studies, Health Sciences Campus, Pharmacy Faculty, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal. Electronic address: [email protected].; CFE - Centre for Functional Ecology, Department of Life Sciences, University of Coimbra, Apartado 3046, 3001-401 Coimbra, Portugal; CEF - Center for Pharmaceutical Studies, Health Sciences Campus, Pharmacy Faculty, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal.; CFE - Centre for Functional Ecology, Department of Life Sciences, University of Coimbra, Apartado 3046, 3001-401 Coimbra, Portugal; CNC - Centre for Neurosciences and Cell Biology, Department of Life Sciences, University of Coimbra, 3001-401 Coimbra, Portugal.; Departamento de Nutrición y Bromatología, Facultad de Veterinaria, Universidad de Santiago de Compostela, Lugo 27002, Spain.; CFE - Centre for Functional Ecology, Department of Life Sciences, University of Coimbra, Apartado 3046, 3001-401 Coimbra, Portugal.; CEF - Center for Pharmaceutical Studies, Health Sciences Campus, Pharmacy Faculty, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal.

DOI: 10.1016/j.chemosphere.2013.12.038

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MeSH Terms: Drug Stability, Environmental Monitoring, Food Chain, Seawater, Seaweed, Sulfathiazole, Sulfathiazoles, Ulva, Water Pollutants, Chemical