GM3 and diabetes.

Jin-ichi Inokuchi

Journal: Glycoconjugate journal 2015;31(3):193-7

PMID: 24399479

Abstract

We demonstrated the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and GM3 ganglioside in adipocytes and propose a working hypothesis "metabolic disorders, such as type 2 diabetes, are membrane microdomain disorders caused by aberrant expression of gangliosides". It is expected that the development of novel diagnosis of metabolic syndrome by identifying the specific ganglioside species and a therapeutic strategy "membrane microdomain ortho-signaling therapy".

Address: Division of Glycopathology, Institute of Molecular Biomembranes and Glycobiology, Tohoku Pharmaceutical University, 4-4-1, komatsushima, Aoba-ku, Sendai, 981-8558, Miyagi, Japan, [email protected].

DOI: 10.1007/s10719-013-9516-4

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https://doi.org/10.1007/s10719-013-9516-4

MeSH Terms: Amino Acid Sequence, Biomarkers, Diabetes Mellitus, G(M3) Ganglioside, Humans, Insulin Resistance, Metabolic Syndrome, Molecular Sequence Data