Post-study caffeine administration enhances memory consolidation in humans.

Daniel Borota, Elizabeth Murray, Gizem Keceli, Allen Chang, Joseph M Watabe, Maria Ly, John P Toscano, Michael A Yassa

Journal: Nature neuroscience 2014;17(2):201-3

PMID: 24413697

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Abstract

It is currently not known whether caffeine has an enhancing effect on long-term memory in humans. We used post-study caffeine administration to test its effect on memory consolidation using a behavioral discrimination task. Caffeine enhanced performance 24 h after administration according to an inverted U-shaped dose-response curve; this effect was specific to consolidation and not retrieval. We conclude that caffeine enhanced consolidation of long-term memories in humans.

Address: Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland, USA.; Department of Chemistry, Johns Hopkins University, Baltimore, Maryland, USA.; 1] Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland, USA. [2] Department of Neurobiology and Behavior, University of California, Irvine, California, USA.

DOI: 10.1038/nn.3623

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MeSH Terms: Adolescent, Adult, Analysis of Variance, Caffeine, Central Nervous System Stimulants, Discrimination, Psychological, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Male, Memory, Long-Term, Neuropsychological Tests, Photic Stimulation, Recognition, Psychology, Saliva, Time Factors, Young Adult