Plaque hemorrhage in carotid artery disease: pathogenesis, clinical and biomechanical considerations.

Zhongzhao Teng, Umar Sadat, Adam J Brown, Jonathan H Gillard

Journal: Journal of biomechanics 2014;47(4):847-58

PMID: 24485514

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Abstract

Stroke remains the most prevalent disabling illness today, with internal carotid artery luminal stenosis due to atheroma formation responsible for the majority of ischemic cerebrovascular events. Severity of luminal stenosis continues to dictate both patient risk stratification and the likelihood of surgical intervention. But there is growing evidence to suggest that plaque morphology may help improve pre-existing risk stratification criteria. Plaque components such a fibrous tissue, lipid rich necrotic core and calcium have been well investigated but plaque hemorrhage (PH) has been somewhat overlooked. In this review we discuss the pathogenesis of PH, its role in dictating plaque vulnerability, PH imaging techniques, marterial properties of atherosclerotic tissues, in particular, those obtained based on in vivo measurements and effect of PH in modulating local biomechanics.

Address: University Department of Radiology, University of Cambridge, UK; Department of Engineering, University of Cambridge, UK. Electronic address: [email protected].; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, UK.; Department of Cardiovascular Medicine, University of Cambridge, UK.; University Department of Radiology, University of Cambridge, UK.

DOI: 10.1016/j.jbiomech.2014.01.013

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MeSH Terms: Biomechanical Phenomena, Carotid Stenosis, Hemorrhage, Humans, Magnetic Resonance Imaging, Plaque, Atherosclerotic, Risk Assessment, Stroke