The other side of the coin: functional and structural versatility of ADF/cofilins.

Gábor Hild, Lajos Kalmár, Roland Kardos, Miklós Nyitrai, Beáta Bugyi

Journal: European journal of cell biology 2015;93(5-6):238-51

PMID: 24836399

Full Text on Elsevier Science View on PubMed

Abstract

Several cellular processes rely on the fine tuning of actin cytoskeleton. A central component in the regulation of this cellular machinery is the ADF-H domain proteins. Despite sharing the same domain, ADF-H domain proteins produce a diverse functional landscape in the regulation of the actin cytoskeleton. Recent findings emphasize that the functional and structural features of these proteins can differ not only between ADF-H families but even within the same family. The structural and evolutional background of this functional diversity is poorly understood. This review focuses on the specific functional characteristics of ADF-H domain proteins and how these features can be linked to structural differences in the ADF-H domain and also to different conformational transitions in actin. In the light of recent discoveries we pay special attention to the ADF/cofilin proteins to find tendencies along which the functional and structural diversification is governed through the evolution.

Address: University of Pécs, Medical School, Department of Biophysics, Szigeti str. 12, H-7624 Pécs, Hungary; Szentágothai Research Center, Ifjúság str. 34, H-7624 Pécs, Hungary.; Institute of Enzymology, Hungarian Academy of Sciences, Research Centre for Natural Sciences, PO Box 7, H-1518 Budapest, Hungary.; University of Pécs, Medical School, Department of Biophysics, Szigeti str. 12, H-7624 Pécs, Hungary; Szentágothai Research Center, Ifjúság str. 34, H-7624 Pécs, Hungary; MTA-PTE Nuclear and Mitochondrial Interactions Research Group, Hungarian Academy of Sciences, Office for Subsidized Research Units, Nádor str. 7, H-1051 Budapest, Hungary.; University of Pécs, Medical School, Department of Biophysics, Szigeti str. 12, H-7624 Pécs, Hungary; Szentágothai Research Center, Ifjúság str. 34, H-7624 Pécs, Hungary. Electronic address: [email protected].

DOI: 10.1016/j.ejcb.2013.12.001

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MeSH Terms: Actin Cytoskeleton, Actin Depolymerizing Factors, Actins, Amino Acid Sequence, Humans, Models, Molecular, Molecular Sequence Data, Protein Structure, Tertiary