Pseudouridine: still mysterious, but never a fake (uridine)!

Felix Spenkuch, Yuri Motorin, Mark Helm

Journal: RNA biology 2015;11(12):1540-54

PMID: 25616362

Abstract

Pseudouridine (Ψ) is the most abundant of >150 nucleoside modifications in RNA. Although Ψ was discovered as the first modified nucleoside more than half a century ago, neither the enzymatic mechanism of its formation, nor the function of this modification are fully elucidated. We present the consistent picture of Ψ synthases, their substrates and their substrate positions in model organisms of all domains of life as it has emerged to date and point out the challenges that remain concerning higher eukaryotes and the elucidation of the enzymatic mechanism.

Address: a Institute of Pharmacy and Biochemistry ; Johannes Gutenberg-University of Mainz ; Mainz , Germany.

DOI: 10.4161/15476286.2014.992278

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MeSH Terms: Escherichia coli, Humans, Intramolecular Transferases, Isoenzymes, Nucleic Acid Conformation, Pseudouridine, RNA, RNA Processing, Post-Transcriptional, RNA, Mitochondrial, RNA, Ribosomal, RNA, Transfer, Amino Acid-Specific, Ribonucleoproteins, Small Nuclear, Ribosomes, Saccharomyces cerevisiae, Uridine, RNA, Guide, CRISPR-Cas Systems