Secondary demyelination disorders and destruction of white matter.

Michael Ryan, Mohannad Ibrahim, Hemant A Parmar

Journal: Radiologic clinics of North America 2014;52(2):337-54

PMID: 24582343

Full Text on Elsevier Science View on PubMed

Abstract

Demyelinating disorders of the central nervous system are characterized by the breakdown of myelin, with or without preservation of the associated axons. Primary demyelinating diseases typically involve loss of myelin with relative sparing of axons. Secondary demyelinating disorders represent a spectrum of white matter disease characterized by damage to neurons or axons with the resultant breakdown of myelin. The pathologic changes seen in secondary demyelinating disorders are varied, ranging from pure demyelination to necrosis with subsequent demyelination. Secondary demyelinating diseases are associated with a wide variety of conditions, including infections/vaccinations, nutritional/vitamin deficiencies, chemical agents, genetic abnormalities, and vascular insult.

Address: Department of Radiology, University of Michigan Health System, 1500 E Medical Center Drive, Ann Arbor, MI 48109-5030, USA.; Department of Radiology, University of Michigan Health System, 1500 E Medical Center Drive, Ann Arbor, MI 48109-5030, USA. Electronic address: [email protected].

DOI: 10.1016/j.rcl.2013.11.007

Link outs

Free resources

Medical:

https://medlineplus.gov/ctscans.html

Other Literature Sources:

https://scite.ai/reports/24582343

Subscription / membership required

Full Text Sources:

MeSH Terms: Axons, Demyelinating Diseases, Humans, Leukoencephalopathies, Magnetic Resonance Imaging, Nerve Fibers, Myelinated, Tomography, X-Ray Computed