Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trials.

Heshu Sulaiman Rahman, Abdullah Rasedee, Swee Keong Yeap, Hemn Hassan Othman, Max Stanley Chartrand, Farideh Namvar, Ahmad Bustamam Abdul, Chee Wun How

Journal: BioMed research international 2015;2014():920742

PMID: 25025076

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Abstract

Zerumbone (ZER) is a naturally occurring dietary compound, present in many natural foods consumed today. The compound derived from several plant species of the Zingiberaceae family that has been found to possess multiple biomedical properties, such as antiproliferative, antioxidant, anti-inflammatory, and anticancer activities. However, evidence of efficacy is sparse, pointing to the need for a more systematic review for assessing scientific evidence to support therapeutic claims made for ZER and to identify future research needs. This review provides an updated overview of in vitro and in vivo investigations of ZER, its cancer chemopreventive properties, and mechanisms of action. Therapeutic effects of ZER were found to be scientifically plausible and could be explained partially by in vivo and in vitro pharmacological activities. Much of the research outlined in this paper will serve as a foundation to explain ZER anticancer bioactivity, which will open the door for the development of strategies in the treatment of malignancies using ZER.

Address: Department of Veterinary Clinical Diagnosis, Faculty of Veterinary Medicine, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, Malaysia ; Institute of Bioscience, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, Malaysia ; Department of Microbiology, Faculty of Veterinary Medicine, University of Sulaimanyah, Sulaymaniyah, Kurdistan Region, Iraq.; Department of Veterinary Clinical Diagnosis, Faculty of Veterinary Medicine, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, Malaysia ; Institute of Bioscience, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, Malaysia.; Institute of Bioscience, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, Malaysia.; Department of Veterinary Clinical Diagnosis, Faculty of Veterinary Medicine, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, Malaysia ; Department of Microbiology, Faculty of Veterinary Medicine, University of Sulaimanyah, Sulaymaniyah, Kurdistan Region, Iraq.; DigiCare Behavioral Research, Casa Grande, AZ, USA.; Institute of Tropical Forestry and Forest Products (INTROP), Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, Malaysia.

DOI: 10.1155/2014/920742

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MeSH Terms: Antioxidants, Apoptosis, Cell Proliferation, Chemoprevention, Diet, Humans, Neoplasms, Sesquiterpenes, Zingiberaceae