Tetraploidy acute promyelocytic leuemia with double t(15;17)/PML-RARA, a case report with review of literature.

Samir M Dalia, Pedro Horna, Ling Zhang

Journal: International journal of clinical and experimental pathology 2015;7(8):5363-8

PMID: 25197424

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Abstract

Acute promyelocytic leukemia (APL) with tetraploidy chromosome harboring t(15;17)(q23;a21) is extremely rare. To date, there are 14 such cases reports that describe this entity, mostly found in Eastern hemisphere. Herein we described a 51-year-old man with a diagnosis of tetraploid acute promyelocytic leukemia with double (15;17) translocations and compare the prototypically clinicopathologic, genetic and molecular findings with those reported in the literature.

Address: H. Lee Moffitt Cancer and Research Institute, Division of Hematological Malignancies and The University of South Florida Tampa, Florida, USA.; H. Lee Moffitt Cancer and Research Institute, Department of Hematopathology and Laboratory Medicine Tampa, Florida, USA.

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MeSH Terms: Antineoplastic Combined Chemotherapy Protocols, Flow Cytometry, Humans, Idarubicin, In Situ Hybridization, Fluorescence, Leukemia, Promyelocytic, Acute, Male, Middle Aged, Oncogene Proteins, Fusion, Tetraploidy, Translocation, Genetic, Tretinoin