Clinical aspects of urea transporters.

Jianhua Ran, Hongkai Wang, Tinghai Hu

Journal: Sub-cellular biochemistry 2015;73():179-91

PMID: 25298346

Abstract

Jk antigens, which were identified as urea transporter B (UT-B) in the plasma membrane of erythrocytes, and which determine the Kidd blood type in humans, are involved in transfusion medicine, and even in organ transplantation. The Jk(a-b-) blood type is a consequence of a silent Slc14A1 gene caused by various mutations related to lineage. In addition, the specific mutations related to hypertension and metabolic syndrome cannot be ignored. Genome-wide association studies established Slc14A1 as a related gene of bladder cancer and some genotypes are associated with higher morbidity. This chapter aims to introduce the clinical significance of urea transporters.

Address: Department of Anatomy and Neuroscience Center, Basic Medical College, Chongqing Medical University, Yixueyuan Road 1, Chongqing, 400016, China, [email protected].

DOI: 10.1007/978-94-017-9343-8_12

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https://dx.doi.org/10.1007/978-94-017-9343-8_12

MeSH Terms: Amino Acid Substitution, Erythrocytes, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Kidd Blood-Group System, Membrane Transport Proteins, Mutation, Risk Factors, Urinary Bladder Neoplasms, Urea Transporters