Curcumin glucuronides: assessing the proliferative activity against human cell lines.

Ashutosh Pal, Bokyung Sung, Basvoju A Bhanu Prasad, Paul T Schuber, Sahdeo Prasad, Bharat B Aggarwal, William G Bornmann

Journal: Bioorganic & medicinal chemistry 2014;22(1):435-9

PMID: 24280069

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Abstract

A gram scale synthesis of the glucuronide metabolites of curcumin were completed in four steps. The newly synthesized curcumin glucuronide compounds 2 and 3 along with curcumin 1 were tested and their anti-proliferative effects against KBM-5, Jurkat cell, U266, and A549 cell lines were reported. Biological data revealed that as much as 1 μM curcumin 1 exhibited anticancer activity and almost 100% cell kill was noted at 10 μM on two out of four cell lines; while curcumin mono-glucuronide 2 as well as di-glucuronide 3 displayed no suppression of cell proliferation.

Address: Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.; Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: [email protected].

DOI: 10.1016/j.bmc.2013.11.006

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MeSH Terms: Cell Line, Tumor, Cell Proliferation, Curcumin, Humans, Jurkat Cells, Structure-Activity Relationship