The role of bacterial phytotoxins in inhibiting the eukaryotic proteasome.

Robert Dudler

Journal: Trends in microbiology 2014;22(1):28-35

PMID: 24284310

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Abstract

The ubiquitin-26S proteasome degradation system (UPS) plays a pivotal role in almost all aspects of plant life, including defending against pathogens. Although the proteasome is important for plant immunity, it has been found to be also exploited by pathogens using effectors to increase their virulence. Recent work on the XopJ effector and syringolin A/syrbactins has highlighted host proteasome inhibition as a virulence strategy of pathogens. This review will focus on these recent developments.

Address: Institute of Plant Biology, University of Zurich, Zollikerstrasse 107, CH-8008 Zurich, Switzerland. Electronic address: [email protected].

DOI: 10.1016/j.tim.2013.10.010

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MeSH Terms: Bacteria, Bacterial Toxins, Plants, Proteasome Endopeptidase Complex, Virulence Factors