Technological applications arising from the interactions of DNA bases with metal ions.

Ki Soo Park, Hyun Gyu Park

Journal: Current opinion in biotechnology 2014;28():17-24

PMID: 24832070

Full Text on Elsevier Science View on PubMed

Abstract

An intense interest has grown in the unique interactions of nucleic acids with metal ions, which lead to the formation of metal-base pairs and the generation of fluorescent nanomaterials. In this review, different types of metal-base pairs, especially those formed from naturally occurring nucleosides, are described with emphasis also being given to recent advances made in employing these complexes to govern enzymatic reactions. The review also contains a comprehensive description of DNA-templated inorganic nanomaterials such as silver nanoclusters which possess excellent fluorescence properties. Finally, a summary is given about how these materials have led to recent advances in the field of nanobiotechnology.

Address: Department of Chemical and Biomolecular Engineering (BK 21+ program), KAIST, Daehak-ro 291, Yuseong-gu, Daejeon 305-701, Republic of Korea.; Department of Chemical and Biomolecular Engineering (BK 21+ program), KAIST, Daehak-ro 291, Yuseong-gu, Daejeon 305-701, Republic of Korea. Electronic address: [email protected].

DOI: 10.1016/j.copbio.2013.10.013

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MeSH Terms: Base Pairing, DNA, Fluorescence, Ions, Metal Nanoparticles, Metals, Nanostructures, Nucleosides, Silver