Ocular manifestations of monoclonal copper-binding immunoglobulin.

Sejal Shah, Edgar M Espana, Curtis E Margo

Journal: Survey of ophthalmology 2014;59(1):115-23

PMID: 24112547

Full Text on Elsevier Science View on PubMed

Abstract

The dense accumulation of copper in Descemet membrane and lens capsule is the characteristic manifestation of a circulating monoclonal antibody with strong affinity for copper. The overproduction of this monoclonal immunoglobulin may be associated with either multiple myeloma or a benign monoclonal gammopathy. Despite prolonged exposure to elevated serum copper, no other tissues in the body are adversely affected by this redox metal. We describe the clinical and pathological findings in a 46-year-old woman with this disorder.

Address: Department of Ophthalmology, University of South Florida Morsani College of Medicine, Tampa, Florida, USA.; Department of Ophthalmology, University of South Florida Morsani College of Medicine, Tampa, Florida, USA; Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, Tampa, Florida, USA.; Department of Ophthalmology, University of South Florida Morsani College of Medicine, Tampa, Florida, USA; Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, Tampa, Florida, USA. Electronic address: [email protected].

DOI: 10.1016/j.survophthal.2013.03.002

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MeSH Terms: Anterior Capsule of the Lens, Cataract Extraction, Ceruloplasmin, Copper, Corneal Diseases, Descemet Membrane, Descemet Stripping Endothelial Keratoplasty, Diagnosis, Differential, Female, Humans, Lens Diseases, Lens Implantation, Intraocular, Middle Aged, Monoclonal Gammopathy of Undetermined Significance, Multiple Myeloma, Spectrometry, X-Ray Emission