PDBsum additions.

Janet M Thornton, Roman A Laskowski, Tjaart A P de Beer, Karel Berka

Journal: Nucleic acids research 2014;42(Database issue):D292-6

PMID: 24153109

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Abstract

PDBsum, http://www.ebi.ac.uk/pdbsum, is a website providing numerous pictorial analyses of each entry in the Protein Data Bank. It portrays the structural features of all proteins, DNA and ligands in the entry, as well as depicting the interactions between them. The latest features, described here, include annotation of human protein sequences with their naturally occurring amino acid variants, dynamic graphs showing the relationships between related protein domain architectures, analyses of ligand binding clusters across different experimental determinations of the same protein, analyses of tunnels in proteins and new search options.

Address: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK and Department of Physical Chemistry, Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacký University Olomouc, tř. 17. listopadu 12, 771 46 Olomouc, Czech Republic.

DOI: 10.1093/nar/gkt940

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MeSH Terms: Cluster Analysis, Computer Graphics, Databases, Protein, Drug Design, Genetic Variation, Humans, Internet, Ligands, Protein Conformation, Protein Structure, Tertiary, Proteins