Imaging of cancer therapy-induced central nervous system toxicity.

Joshua P Klein, Jörg Dietrich

Journal: Neurologic clinics 2014;32(1):147-57

PMID: 24287388

Full Text on Elsevier Science View on PubMed

Abstract

Cancer therapy, including radiation and chemotherapy, can be associated with harmful effects to the central nervous system. Recognition of classical neurotoxic syndromes is critical to appropriately guide and optimize patient management. As a result of cancer therapy-induced toxicity, patients may present with acute, subacute, and chronic neurologic symptoms that can be misinterpreted as tumor recurrence, infection, or paraneoplastic syndromes. In this review the advantages and limitations of various neuroimaging modalities such as computed tomography, magnetic resonance imaging, and positron emission tomography, frequently used in patients with cancer who present with diverse neurotoxic syndromes, are highlighted.

Address: Division of Neuro-Oncology, Department of Neurology, Massachusetts General Hospital Cancer Center, Center for Regenerative Medicine, Harvard Medical School, 55 Fruit Street, Yawkey 9E, Boston, MA 02114, USA. Electronic address: [email protected].

DOI: 10.1016/j.ncl.2013.07.004

Link outs

Free resources

Other Literature Sources:

https://scite.ai/reports/24287388

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-HLA-B-1

Subscription / membership required

Full Text Sources:

MeSH Terms: Antineoplastic Agents, Central Nervous System Diseases, Humans, Neuroimaging, Radiotherapy