Are conjugated linolenic acid isomers an alternative to conjugated linoleic acid isomers in obesity prevention?

Jonatan Miranda, Noemi Arias, Alfredo Fernández-Quintela, María del Puy Portillo

Journal: Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 2015;61(4):209-19

PMID: 24029409

Full Text on Ediciones Doyma, S.L. View on PubMed

Abstract

Despite its benefits, conjugated linoleic acid (CLA) may cause side effects after long-term administration. Because of this and the controversial efficacy of CLA in humans, alternative biomolecules that may be used as functional ingredients have been studied in recent years. Thus, conjugated linolenic acid (CLNA) has been reported to be a potential anti-obesity molecule which may have additional positive effects related to obesity. According to the results reported in obesity, CLNA needs to be given at higher doses than CLA to be effective. However, because of the few studies conducted so far, it is still difficult to reach clear conclusions about the potential use of these CLNAs in obesity and its related changes (insulin resistance, dyslipidemia, or inflammation).

Address: Grupo Nutrición y Obesidad, Departamento de Farmacia y Ciencias de los Alimentos, Facultad de Farmacia, Universidad del País Vasco, Vitoria, España; CIBERobn, Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, España. Electronic address: [email protected].; Grupo Nutrición y Obesidad, Departamento de Farmacia y Ciencias de los Alimentos, Facultad de Farmacia, Universidad del País Vasco, Vitoria, España; CIBERobn, Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, España.

DOI: 10.1016/j.endonu.2013.04.016

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MeSH Terms: Humans, Hyperlipidemias, Isomerism, Linoleic Acids, Conjugated, Obesity, alpha-Linolenic Acid