Isotretinoin: update on controversial issues.

Joseph C English, Noel Prevost

Journal: Journal of pediatric and adolescent gynecology 2014;26(5):290-3

PMID: 24147278

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Abstract

Acne vulgaris is a commonly seen dermatologic condition that plagues millions and can be very psychosocially disabling. Severe and recalcitrant acne is typically treated with isotretinoin. Isotretinoin is a synthetic vitamin A derivative that has been available since 1982.This therapeutic option has been the most effective at putting severe and recalcitrant acne vulgaris into remission. Despite its effectiveness,it has been associated with inflammatory bowel disease, depression, suicidality, and teratogenicity. We review the current literature on isotretinoin's role in inflammatory bowel disease, depression, and suicidality. In addition, we review whether or not the iPledge program has been successful at reducing pregnancy rates while on isotretinoin.

DOI: 10.1016/j.jpag.2013.05.007

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MeSH Terms: Acne Vulgaris, Adolescent, Depression, Dermatologic Agents, Female, Humans, Inflammatory Bowel Diseases, Isotretinoin, Pregnancy, Pregnancy in Adolescence, Risk Factors, Suicidal Ideation, Teratogens