Emergence of a C-terminal seven-amino-acid elongation of NS1 in around 1950 conferred a minor growth advantage to former seasonal influenza A viruses.

Florens Lohrmann, Ronald Dijkman, Silke Stertz, Volker Thiel, Otto Haller, Peter Staeheli, Georg Kochs

Journal: Journal of virology 2013;87(20):11300-3

PMID: 23926347

Free Full Text on PubMed Central View on PubMed

Abstract

Influenza A viruses circulating in humans from ∼1950 to ∼1987 featured a nonstructural (NS1) protein with a C-terminal extension of seven amino acids. The biological significance of this NS1 elongation remained elusive. We observed that replication kinetics of the wild-type virus A/Hong Kong/01/68 (H3N2) and a mutant encoding a truncated NS1 were indistinguishable in most experimental systems. However, wild-type virus outcompeted the mutant during mixed infections, suggesting that the NS1 extension conferred minor growth advantages.

Address: Institute for Virology, University Medical Center Freiburg, Freiburg, Germany.

DOI: 10.1128/JVI.01271-13

Link outs

Free resources

Full Text Sources:

Medical:

https://medlineplus.gov/flu.html

Other Literature Sources:

https://scite.ai/reports/23926347

Subscription / membership required

Full Text Sources:

https://journals.asm.org/doi/10.1128/JVI.01271-13?...

MeSH Terms: Evolution, Molecular, Hong Kong, Humans, Influenza A Virus, H3N2 Subtype, Influenza, Human, Mutagenesis, Insertional, Viral Nonstructural Proteins, Virulence, Virus Replication