Use of infrared attenuated total reflectance spectroscopy for the in vivo measurement of hydration level and silicone distribution in the stratum corneum following skin coverage by polymeric dressings.

M Branagan, D H Chenery, S Nicholson

Journal: Skin pharmacology and applied skin physiology 2000;13(3-4):157-64

PMID: 10859534

Abstract

The ability of wound dressings to hydrate the stratum corneum has been tested experimentally using attenuated total reflectance (ATR) infrared spectroscopy. A silicone gel dressing was able to hydrate the stratum corneum to the extent that its water content within the sampled volume was >60% after 5 h of contact compared with about 15% of normal exposed skin and about 30% for a highly permeable hydrophilic polyurethane dressing. An ATR method was devised to determine the presence and depth of penetration of silicone in the stratum corneum as a result of skin coverage by the polymeric dressing.

Address: Smith and Nephew Group Research Centre, York Science Park, Heslington, York, UK.

DOI: 10.1159/000029921

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https://assays.cancer.gov/CPTAC-3214

MeSH Terms: Algorithms, Bandages, Humans, Silicone Gels, Silicones, Skin, Skin Absorption, Spectrophotometry, Infrared, Time Factors, Water