A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen.

A A Spasov, G K Wikman, V B Mandrikov, I A Mironova, V V Neumoin

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 2000;7(2):85-9

PMID: 10839209

Full Text on Elsevier Science View on PubMed

Abstract

The objective was to investigate the stimulating and normalizing effect of the adaptogen Rhodiola rosea extract SHR-5 in foreign students during a stressful examination period. The study was performed as a double-blind, randomized and placebo-controlled with low repeated dose regime. The study drug and the placebo were taken for 20 days by the students during an examination period. The physical and mental performance were assessed before and after the period, based on objective as well as on subjective evaluation. The most significant improvement in the SHR-5 group was seen in physical fitness, mental fatigue and neuro-motoric tests (p <0.01). The self-assessment of the general well-being was also significantly (p < 0.05) better in the verum group. No significance was seen in the correction of text tests or a neuro-muscular tapping test. The overall conclusion is that the study drug gave significant results compared to the placebo group but that the dose level probably was suboptimal.

Address: Volgograd Medical Academy, Russia.

DOI: 10.1016/S0944-7113(00)80078-1

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MeSH Terms: Adolescent, Adult, Double-Blind Method, Educational Measurement, Emotions, Fatigue, Humans, India, Maze Learning, Phytotherapy, Pilot Projects, Plant Extracts, Plants, Medicinal, Psychomotor Performance, Pulse, Stress, Psychological, Students, Medical, Sweden