Unexpected MH deaths without exposure to inhalation anesthetics in pediatric patients.

Sheila M Muldoon, Barbara W Brandom

Journal: Paediatric anaesthesia 2014;23(9):851-4

PMID: 23848295

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Abstract

Children, later found to have ryanodine receptor type one variants (RYR1), died without exposure to inhalation anesthetics. Family members with the same RYR1 variants had contracture tests consistent with susceptibility to malignant hyperthermia or in vitro testing showed increased sensitivity to RYR1 agonist.

Address: Department of Anesthesiology, North American Malignant Hyperthermia Registry of the Malignant Hyperthermia Association of the United States, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. [email protected]

DOI: 10.1111/pan.12224

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MeSH Terms: Anesthesia, General, Anesthetics, Inhalation, Child, Child, Preschool, Genotype, Halothane, Humans, Malignant Hyperthermia, Neuromuscular Depolarizing Agents, Rhabdomyolysis, Ryanodine Receptor Calcium Release Channel, Succinylcholine