The role of adipocytes in the modulation of iron metabolism in obesity.

S Coimbra, C Catarino, A Santos-Silva

Journal: Obesity reviews : an official journal of the International Association for the Study of Obesity 2014;14(10):771-9

PMID: 23841713

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Abstract

A tight relationship between iron deficiency and obesity is known to exist. The chronic low-grade inflammation that characterizes obesity enhances hepcidin production, the principal regulator of iron availability. Adipose tissue is known to secret interleukin-6 and leptin that triggers hepcidin production. It was found that adipose tissue also expresses hepcidin and hemojuvelin, a regulator of hepcidin production. These recent findings suggest that adipose tissue may have an important role in erythropoiesis particularly on obesity that is still poorly clarified. This paper discusses these findings and how they can modulate erythropoiesis.

Address: Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal; CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Gandra-PRD, Portugal.

DOI: 10.1111/obr.12057

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MeSH Terms: Adipocytes, Adipose Tissue, Erythropoiesis, GPI-Linked Proteins, Hemochromatosis Protein, Hepcidins, Humans, Interleukin-6, Iron, Iron Deficiencies, Leptin, Obesity