The effect of vitamin A supplementation on retinoic acid-related orphan receptor γt (RORγt) and interleukin-17 (IL-17) gene expression in Avonex-treated multiple sclerotic patients.

Mohammad Reza Eshraghian, Eisa Salehi, Mohammad Ali Sahraian, Sama Bitarafan, Niyaz Mohammadzadeh Honarvar, Mohammad Hossein Harirchian, Fariba Koohdani, Feridoun Siassi, Mina Abdolahi, Ali Akbar Saboor-Yarghi

Journal: Journal of molecular neuroscience : MN 2014;51(3):749-53

PMID: 23868508

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Abstract

The aim of this study was to investigate the role of vitamin A on RORγt and IL-17 gene expression in multiple sclerotic patients. Patients in the vitamin A group received 25,000 IU retinyl palmitate per day, while patients in the placebo group took one capsule of placebo per day for 6 months. Gene expression was measured by real-time PCR at the first and end of the study. The results of this study show that vitamin A downregulates IL-17 and RORγt gene expression. No changes in gene expression occurred in the placebo group.

Address: Cellular and Molecular Nutrition Department, School of Nutritional Sciences and Dietetics, Tehran university of Medical Sciences, Tehran, Iran.

DOI: 10.1007/s12031-013-0058-9

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https://dx.doi.org/10.1007/s12031-013-0058-9

MeSH Terms: Adult, Down-Regulation, Female, Humans, Interferon beta-1a, Interferon-beta, Interleukin-17, Male, Multiple Sclerosis, Nuclear Receptor Subfamily 1, Group F, Member 3, Transcription, Genetic, Vitamin A, Vitamins