Effects of oral casokefamide on plasma levels, tolerance, and intestinal transit in man.

E Schulte-Frohlinde, W Reindl, D Bierling, C Lersch, V Brantl, H Teschemacher, V Schusdziarra

Journal: Peptides 2000;21(3):439-42

PMID: 10793229

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Abstract

Food-derived opioid peptides such as beta-casomorphins are of interest for treatment of chronic diarrhea. The beta-casomorphin analog casokefamide was administered orally at doses of 5.5, 8.0, and 16.0 mg to 10 healthy male volunteers, respectively. Dose-dependent increases of plasma levels with a maximum of 350 fmol/l were determined. No side-effects due to casokefamide has been observed. In comparison to placebo, casokefamide showed a trend toward prolongation of oro-caecal transit time. Orally applied casokefamide is well tolerated and may represent a useful tool for treatment of diarrhea in the future.

Address: Department of Medicine II, Technical University of Munich, Ismaningerstrasse 22, 81675, Munich, Germany. [email protected]

DOI: 10.1016/s0196-9781(00)00166-2

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MeSH Terms: Administration, Oral, Dose-Response Relationship, Drug, Endorphins, Gastrointestinal Transit, Humans, Iodine Radioisotopes, Lactulose, Male, Placebos