Meldonium decreases the diet-increased plasma levels of trimethylamine N-oxide, a metabolite associated with atherosclerosis.

Maija Dambrova, Elina Skapare-Makarova, Ilze Konrade, Osvalds Pugovics, Solveiga Grinberga, Dace Tirzite, Ramona Petrovska, Ivars Kalvins, Edgars Liepins

Journal: Journal of clinical pharmacology 2014;53(10):1095-8

PMID: 23893520

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Abstract

Address: Latvian Institute of Organic Synthesis, Riga, Latvia; Riga Stradins University, Riga, Latvia.

DOI: 10.1002/jcph.135

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MeSH Terms: Adult, Atherosclerosis, Cardiovascular Agents, Carnitine, Diet, Female, HEK293 Cells, Humans, Male, Methylamines, Methylhydrazines, Organic Cation Transport Proteins, Seafood, Solute Carrier Family 22 Member 5