Application of ursodeoxycholic acid (UDCA) in the therapy of liver and biliary duct diseases in children.

D M Lebensztejn

Journal: Medical science monitor : international medical journal of experimental and clinical research 2001;6(3):632-6

PMID: 11208384

Full Text on International Scientific Literature, Ltd. View on PubMed

Abstract

The paper discusses the experience accumulated so far in the field of application of ursodeoxycholic acid (UDCA) in selected disorders of the liver and biliary ducts in the developmental age population. In the aforementioned diseases, chronic administration of UDCA is safe, reduces the clinical symptoms, improves the biochemical parameters, and even the histopathologic picture of the affected organ. Such a therapy should be instituted in order to improve the quality of life, reduce the incidence of complications and postpone the transplantation of the liver till the time the child is older.

Address: 3rd Department of Pediatric Diseases, Medical University of Białystok, ul. Waszyngtona 17, 15-274 Białystok, Poland.

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MeSH Terms: Alagille Syndrome, Bile Duct Diseases, Child, Cholagogues and Choleretics, Cholestasis, Intrahepatic, Cystic Fibrosis, Humans, Liver Diseases, Parenteral Nutrition, Total, Ursodeoxycholic Acid