Antimycotic agents in oral candidosis: an overview: 2. Treatment of oral candidosis.

L P Samaranayake, A N Ellepola

Journal: Dental update 2001;27(4):165-70, 172-4

PMID: 11218451

Abstract

As both humans and fungi are eukaryotic organisms, antifungal agents affect their cellular metabolism. Thus, a relatively few antifungals with minimal toxicity and side-effects are available compared with a plethora of antibacterials. These agents currently prescribed in dentistry belong to two major groups, the polyenes (nystatin and amphotericin B) and the azoles (imidazoles and triazoles). A newly recognized phenomenon known as the post-antifungal effect implies that antifungals, even at sub-therapeutic concentrations, may suppress the virulent attributes of yeasts, especially intra-orally where topical drug levels fluctuate dramatically during dosing intervals.

Address: Department of Oral Medicine & Periodontology, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka.

DOI: 10.12968/denu.2000.27.4.165

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MeSH Terms: Amphotericin B, Antifungal Agents, Candida, Candidiasis, Oral, Clotrimazole, Drug Interactions, Drug Resistance, Microbial, Fluconazole, Humans, Itraconazole, Ketoconazole, Miconazole, Nystatin, Virulence