Addisonian pigmentation and vitamin B₁₂ deficiency: a case series and review of the literature.

Madhukara Jithendriya, Sendhil Kumaran, Ishwara B P

Journal: Cutis 2014;92(2):94-9

PMID: 24087784

Full Text on Frontline Medical Communications Inc View on PubMed

Abstract

Skin changes associated with vitamin B₁₂ deficiency are common. In most cases, patients present primarily with systemic involvement (eg, megaloblastic anemia and/or neurologic effects), and additional cutaneous changes related to the diagnosis are noted as incidental findings. The role of vitamin B₁₂ deficiency in the etiology of Addisonian pigmentation has not been well studied. We discuss the importance of testing vitamin B₁₂ levels in patients who present for evaluation of generalized hyperpigmentation. Various cutaneous changes associated with vitamin B₁₂ deficiency also are reviewed.

Address: Department of Dermatology, Saint John's Medical College Hospital, Surjapur Rd, Kormangala Bangalore-560034, Karnataka State, India. [email protected].

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MeSH Terms: Adult, Anemia, Megaloblastic, Female, Humans, Hyperpigmentation, Male, Middle Aged, Skin Diseases, Vitamin B 12 Deficiency, Young Adult