Assessment of steroidogenesis and steroidogenic enzyme functions.

Van Luu-The

Journal: The Journal of steroid biochemistry and molecular biology 2013;137():176-82

PMID: 23770321

Full Text on Elsevier Science View on PubMed

Abstract

There is some confusion in the literature about steroidogenesis in endocrine glands and steroidogenesis in peripheral intracrine tissues. The objective of the present review is to bring some clarifications and better understanding about steroidogenesis in these two types of tissues. Concerns about substrate specificity, kinetic constants and place of enzymes in the pathway have been discussed. The role of 17α-hydroxylase/17-20 lyase (CYP17A1) in the production of dehydroepiandrosterone and back-door pathways of dihydrotestosterone biosynthesis is also analyzed. This article is part of a Special Issue entitled "Synthesis and biological testing of steroid derivatives as inhibitors".

Address: Research Center in Molecular Endocrinology, Oncology and Human Genomics (CREMOGH) and Department of Molecular Medicine, Faculty of Medicine, Laval University and the CHU de Quebec Research Center, Quebec City, Canada. Electronic address: [email protected].

DOI: 10.1016/j.jsbmb.2013.05.017

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MeSH Terms: Humans, Steroid 17-alpha-Hydroxylase, Steroids