Lack of association of S100β and neuron-specific enolase with mortality in critically ill patients.

Roberta Candal de Macedo, Cristiane Damiani Tomasi, Vinicius René Giombelli, Sarah Cascaes Alves, Maria de Lourdes Ugioni Bristot, Maria Fernanda Topanotti Locks, Fabrícia Petronilho, Carmen Grandi, João Quevedo, Felipe Dal-Pizzol, Cristiane Ritter

Journal: Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 2014;35(3):267-70

PMID: 24142088

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Abstract

OBJECTIVE

To evaluate the relationship between brain damage biomarkers and mortality in the intensive care unit (ICU).

METHODS

The sample comprised 70 patients admitted to an ICU. Blood samples were collected from all patients on ICU admission, and levels of S100β and neuron-specific enolase (NSE) were determined by ELISA.

RESULTS

Acute Physiologic and Chronic Health Evaluation (APACHE II) score was associated with mortality, but NSE and S100β were not associated with this outcome. In contrast, S100β levels were significantly higher in delirious and non-delirious patients who required mechanical ventilation during ICU stay.

CONCLUSION

Levels of brain biomarkers at the time of ICU admission did not predict mortality in critically ill patients.

Address: National Science and Technology Institute for Translational Medicine, Laboratory of Experimental Pathophysiology, CriciúmaSC, Brazil.

DOI: 10.1590/1516-4446-2012-0835