Ascending dose-controlled trial of beloranib, a novel obesity treatment for safety, tolerability, and weight loss in obese women.

T E Hughes, D D Kim, J Marjason, J Proietto, J P Whitehead, J E Vath

Journal: Obesity (Silver Spring, Md.) 2014;21(9):1782-8

PMID: 23512440

Abstract

OBJECTIVE

Evaluate the safety and tolerability of beloranib, a fumagillin-class methionine aminopetidase-2 (MetAP2) inhibitor, in obese women over 4 weeks.

DESIGN AND METHODS

Thirty-one obese (mean BMI 38 kg/m2) women were randomized to intravenous 0.1, 0.3, or 0.9 mg/m2 beloranib or placebo twice weekly for 4 weeks (N = 7, 6, 9, and 9).

RESULTS

The most frequent AEs were headache, infusion site injury, nausea, and diarrhea. Nausea and infusion site injury occurred more with beloranib than placebo. The most common reason for discontinuation was loss of venous access. There were no clinically significant abnormal laboratory findings. In subjects completing 4 weeks, median weight loss with 0.9 mg/m2 beloranib was -3.8 kg (95% CI -5.1, -0.9; N = 8) versus -0.6 kg with placebo (-4.5, -0.1; N = 6). Weight change for 0.1 and 0.3 mg/m2 beloranib was similar to placebo. Beloranib (0.9 mg/m2) was associated with a significant 42 and 18% reduction in triglycerides and LDL-cholesterol, as well as improvement in C-reactive protein and reduced sense of hunger. Changes in β-hydroxybutyrate, adiponectin, leptin, and fibroblast growth factor-21 were consistent with the putative mechanism of MetAP2 inhibition. Glucose and blood pressure were unchanged.

CONCLUSIONS

Beloranib treatment was well tolerated and associated with rapid weight loss and improvements in lipids, C-reactive protein, and adiponectin.

Address: Zafgen, Inc., Cambridge, MA, USA.

DOI: 10.1002/oby.20356

Link outs

Free resources

Full Text Sources:

https://onlinelibrary.wiley.com/doi/10.1002/oby.20...

Medical:

https://medlineplus.gov/weightcontrol.html

Other Literature Sources:

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-CRP-1

MeSH Terms: 3-Hydroxybutyric Acid, Adiponectin, Aminopeptidases, Anti-Obesity Agents, Aspergillus, Biological Products, Blood Glucose, Blood Pressure, C-Reactive Protein, Cholesterol, LDL, Cyclohexanes, Double-Blind Method, Fatty Acids, Unsaturated, Female, Fibroblast Growth Factors, Glycoproteins, Humans, Hunger, Infusions, Intravenous, Leptin, Lipids, Methionyl Aminopeptidases, Middle Aged, Obesity, Sesquiterpenes, Triglycerides, Weight Loss