Efficacy of vitamin E to prevent dermal complications of isotretinoin.

Farideh Goforoushan, Hamideh Azimi, Mohamad Goldust

Journal: Pakistan journal of biological sciences : PJBS 2014;16(11):548-50

PMID: 24498826

Abstract

Acne treatment depends on whether patents have a mild, moderate, or severe type of acne. The aim of this study was to compare the using of Isotretinoin (Rokutan) with and without oral vitamin E in treating acne. This study was performed on 60 patients on 0.5 mg/kg/day isotretinoin treatment for 6 months. The first group received 800 IU day(-1) Vit E during treatment and the second group recieved 800 Iu day(-1) cod liver oil capsules. All patients were observed for the complications at 1th, 4th and 6th weeks during treatment. Cheilitis was the most common side effect among these patients (69%). Epistaxis was the second side effect in both groups (22%). Other side effects were xerosis, pruritus, epigastric pain and nail fragility. The frequency and the severity of complications were less common at 4th and 6th weeks of treatment. Isotretinoin is a useful and effective drug in treating severe and treatment-resistance acne lesions.

Address: Department of Dermatology, Tabriz University of Medical Sciences, Tabriz, Iran.; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

DOI: 10.3923/pjbs.2013.548.550

Link outs

Free resources

Medical:

https://medlineplus.gov/acne.html

Other Literature Sources:

https://scite.ai/reports/24498826

MeSH Terms: Acne Vulgaris, Administration, Oral, Adolescent, Adult, Capsules, Cheilitis, Chi-Square Distribution, Cod Liver Oil, Dermatologic Agents, Epistaxis, Female, Humans, Isotretinoin, Male, Severity of Illness Index, Time Factors, Treatment Outcome, Vitamin E, Young Adult