Erythrocyte folate content and serum folic acid and homocysteine levels in preeclamptic primigravidae teenagers living at high altitude.

OBJECTIVE

To measure erythrocyte folate content and serum folic acid and homocysteine (Hcy) levels in preeclamptic primigravidae teenagers living at high altitude.

METHODS

Measured analytes were compared to those found in normal teen controls.

RESULTS

Teenagers complicated with preeclampsia displayed significantly lower hematocrit and erythrocyte folic acid levels with higher serum Hcy levels as compared to controls (36.40 ± 4.90 vs. 38.99 ± 2.89 %, 493.80 ± 237.30 vs. 589.90 ± 210.60 ng/mL, and 7.29 ± 2.52 vs. 5.97 ± 1.41 μmol/L, respectively, p < 0.05). There was a non-significant trend for lower serum folic acid levels among preeclampsia teenagers. Serum and erythrocyte folic acid levels positively correlated in preeclampsia teenagers, and levels of both analytes inversely correlated with Hcy levels.

CONCLUSION

This pilot study found that teenagers complicated with preeclampsia living at higher altitude displayed lower erythrocyte folate content in addition to higher serum Hcy levels. More research is warranted to determine the clinical implications of these findings.