Studying the effect of antioxidants on cytogenetic manifestations of solvent exposure in the paint industry.

Aamal El Safty, Fateheya Mohamed Metwally, Aisha Mohammed Samir, Amir ElShahawy, Ehab Abdel Raouf

Journal: Toxicology and industrial health 2016;31(12):1087-94

PMID: 23625906

Abstract

OBJECTIVE

To investigate the antioxidant role in reversing cytogenetic changes caused by solvent exposure in paint industry.

SUBJECTS AND METHODS

A prospective controlled clinical trial was performed on 39 workers exposed to solvents and 39 workers not exposed to solvents by supplying a mixture of antioxidant vitamins (A, C, E and selenium) and the after effects of such regimen were analyzed. Environmental monitoring was carried out for air concentrations of different solvents at workplace. Exposed group was cytogenetically tested before and after giving the mixture of antioxidant vitamins for 1 month duration.

RESULTS

Frequency of chromosomal aberrations (CAs) and the mean of sister chromatid exchanges (SCEs) were statistically significantly higher among exposed workers than among controls. After the supplementation of antioxidants, there was a statistically significant decrease in the frequency of CAs, and 88% abnormal levels of SCEs were back to normal levels.

CONCLUSION

Antioxidant supplementation decreases the frequency of CAs and SCEs among exposed workers.

Address: Department of Industrial Medicine and Occupational Diseases, Faculty of Medicine, Cairo University, Egypt.; Department of Environmental and Occupational Medicine, National Research Center, Egypt.; Department of Industrial Medicine and Occupational Diseases, Faculty of Medicine, Cairo University, Egypt [email protected].; Department of Research on Children with Special Needs, National Research Center, Egypt.

DOI: 10.1177/0748233713486957

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MeSH Terms: Air Pollutants, Occupational, Air Pollution, Indoor, Antioxidants, Ascorbic Acid, Chromosome Aberrations, Dietary Supplements, Directly Observed Therapy, Egypt, Environmental Monitoring, Humans, Ink, Male, Middle Aged, Mutagens, Neoplasms, Occupational Exposure, Paint, Selenium, Sister Chromatid Exchange, Solvents, Vitamin A, Vitamin E