Metal-mediated targeting in the body.

Xuan Tang, Xiangyang Liang

Journal: Chemical biology & drug design 2013;81(3):311-22

PMID: 23164152

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Abstract

Metal ions are important for many biological processes and are steadily available in the human body. Metal concentrations can be extremely high in diseased areas of various pathological conditions. Some synthetic and natural drugs need to be activated by metal ions as prodrugs. In this review, we provide a few examples to illustrate how metal ions activate and mediate drug targeting in the body. This knowledge may be helpful for the development of more effective drugs and pharmaceutical formulations.

Address: College of Chemistry and Chemical Engineering, Xi'an Shiyou University, Xi'an 710065, China.

DOI: 10.1111/cbdd.12090

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MeSH Terms: Anti-Inflammatory Agents, Non-Steroidal, Benzylamines, Bleomycin, Cyclams, DNA, Drug Design, Duocarmycins, Heterocyclic Compounds, Humans, Indoles, Ions, Metals, Organophosphonates, Prodrugs, Pyrrolidinones